Claudin 3 Proteins

Protein Information

Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.

Synonyms

AI182374; C7orf1; claudin 3; claudin-3; CLDN3; clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; Cpetr2; hRVP1; integral membrane protein claudin-3; mRVP1; Rat ventral prostate.1 protein; Rat ventral prostate.1 protein homolog; RVP1; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein